Regulation of protein folding

Across TCGA patient cohorts, RNA activity of the Regulation of protein folding pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COMP, TIMP2, and CRTAP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein folding activity versus COMP in COAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	COMP →	+1.017	+0.032	<.001	<.001	3	7
BRCA	TIMP2 →	+0.553	+0.028	<.001	<.001	3	6
BRCA	CRTAP →	+0.568	+0.048	<.001	<.001	3	6
OV	DNAJB2 →	+0.291	+0.048	<.001	.001	3	6
GBM	IKBIP →	+0.707	+0.063	<.001	<.001	3	6
OV	PLS3 →	+0.627	+0.047	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903332 vs COMP — COAD

Explore this scatter interactively →