Regulation of protein folding

Across TCGA cell cohorts, RNA activity of the Regulation of protein folding pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPS30, MTA2, and SLC7A11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPS30 grouped by Regulation of protein folding-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MRPS30 →	+1.531	+0.246	.005	.005	2	5
OVARY	MTA2 →	+0.415	+0.127	.002	<.001	3	3
OVARY	SLC7A11 →	+1.739	+0.129	<.001	<.001	3	3
OVARY	ATG16L2 →	+1.081	+0.120	<.001	.002	3	3
OVARY	IST1 →	+0.627	+0.121	.001	.009	3	3
OVARY	CEP290 →	+0.629	+0.147	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPS30 by Regulation of protein folding activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →