Positive regulation of protein modification by small protein conjugation or removal

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein modification by small protein conjugation or removal pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATM, ESRRG, and RAMP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein modification by small protein conjugation or removal activity versus GATM in HNSC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GATM →	-0.766	-0.157	.003	.001	3	4
BRCA	ESRRG →	-1.058	-0.144	.003	<.001	3	4
BRCA	RAMP2 →	-0.938	-0.119	<.001	<.001	3	4
BRCA	CCNB1 →	+0.876	+0.120	.001	.003	3	4
BRCA	YARS1 →	+0.699	+0.195	<.001	<.001	3	4
BRCA	CDCA8 →	+0.909	+0.109	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903322 vs GATM — HNSC

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