Positive regulation of protein modification by small protein conjugation or removal

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein modification by small protein conjugation or removal pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF1A, SLC43A1, and SERTAD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNFRSF1A grouped by Positive regulation of protein modification by small protein conjugation or removal-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TNFRSF1A →	-2.875	-0.219	.001	.007	3	4
STOMACH	SLC43A1 →	+2.622	+0.134	<.001	.002	3	4
STOMACH	SERTAD1 →	-1.146	-0.119	.009	.008	3	4
LIVER	GRK5 →	-1.052	-0.165	.007	.007	3	4
BREAST	CHST5 →	+0.150	+0.134	<.001	<.001	3	4
CNS	ABHD12 →	-1.083	-0.175	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNFRSF1A by Positive regulation of protein modification by small protein conjugation or removal activity — BLOOD_Lymphoma

Explore this box plot interactively →