Positive regulation of protein maturation

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein maturation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM1, ANXA2, and ADAM9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein maturation activity versus TPM1 in BONE (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TPM1 →	+4.179	+0.331	<.001	.001	3	8
LUNG_SCLC	ANXA2 →	+3.272	+0.248	.002	.002	2	8
BONE	ADAM9 →	+2.373	+0.461	.005	<.001	3	7
SKIN	GSN →	+1.410	+0.202	.002	.007	3	6
LIVER	GBP2 →	+3.554	+0.398	.007	.006	3	6
LIVER	S100A10 →	+4.040	+0.433	.004	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903319 vs TPM1 — BONE

Explore this scatter interactively →