Positive regulation of protein maturation

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein maturation pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANXA2, MYH9, and BAG2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein maturation activity versus ANXA2 in LUNG_SCLC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANXA2 →	+3.322	+0.291	<.001	<.001	3	14
BONE	MYH9 →	+1.757	+0.390	<.001	<.001	3	11
SKIN	BAG2 →	+0.901	+0.138	.004	.003	2	12
LUNG_NSCLC_LUSC	AHNAK →	+3.647	+0.464	.001	.002	3	11
SOFT_TISSUE	MYL6 →	+2.063	+0.452	<.001	<.001	3	11
BONE	ACTN4 →	+2.040	+0.452	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903319 vs ANXA2 — LUNG_SCLC

Explore this scatter interactively →