Negative regulation of protein maturation

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein maturation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP2, CCL18, and CP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein maturation activity versus STXBP2 in GBM (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STXBP2 →	+0.498	+0.259	<.001	<.001	3	5
GBM	CCL18 →	+1.012	+0.213	<.001	<.001	3	5
GBM	CP →	+0.735	+0.261	<.001	<.001	3	5
LSCC	CTSL →	+0.281	+0.356	<.001	<.001	3	5
GBM	ALOX5 →	+0.643	+0.216	<.001	<.001	3	5
GBM	PTX3 →	+0.950	+0.206	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903318 vs STXBP2 — GBM

Explore this scatter interactively →