Negative regulation of protein maturation

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein maturation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX11, FOS, and EBNA1BP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STX11 grouped by Negative regulation of protein maturation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	STX11 →	-0.723	-1.306	.005	.002	3	5
LUNG_SCLC	FOS →	-3.963	-1.386	.001	.002	3	5
BREAST	EBNA1BP2 →	-0.633	-0.816	.001	<.001	3	5
BLOOD_Leukemia	TBRG1 →	-1.002	-1.084	<.001	.002	3	5
CNS	SHB →	-0.909	-1.020	.006	<.001	3	4
CNS	MAP11 →	-0.686	-0.810	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STX11 by Negative regulation of protein maturation activity — PANCREAS

Explore this box plot interactively →