Negative regulation of protein maturation

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein maturation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK3, BTK, and UBE2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEK3 grouped by Negative regulation of protein maturation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NEK3 →	+0.156	+0.144	.004	.002	3	6
KIDNEY	BTK →	-0.198	-0.153	<.001	<.001	3	5
KIDNEY	UBE2A →	+0.140	+0.145	.001	.001	3	5
LUNG_SCLC	ATP6V0A4 →	+0.253	+0.244	.009	.001	3	4
LUNG_SCLC	GPR158 →	+0.195	+0.290	.001	.004	3	4
CNS	C16orf87 →	-0.210	-0.210	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEK3 by Negative regulation of protein maturation activity — CNS

Explore this box plot interactively →