Negative regulation of protein maturation

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein maturation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QSOX1, MICAL2, and SPOCD1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein maturation activity versus QSOX1 in BONE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	QSOX1 →	+3.299	+0.268	<.001	<.001	3	16
BONE	MICAL2 →	+3.570	+0.215	<.001	<.001	3	14
BONE	SPOCD1 →	+3.086	+0.172	<.001	<.001	3	13
BONE	ZYX →	+1.461	+0.203	<.001	<.001	3	13
BONE	THBS1 →	+5.733	+0.179	<.001	<.001	3	12
BONE	COL6A1 →	+4.193	+0.267	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903318 vs QSOX1 — BONE

Explore this scatter interactively →