Regulation of protein maturation

Across TCGA cell cohorts, RNA activity of the Regulation of protein maturation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN1, RAC1, and MAX, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLN1 grouped by Regulation of protein maturation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TLN1 →	+0.306	+0.107	.002	<.001	3	7
LARGE_INTESTINE	RAC1 →	+0.551	+0.126	.007	.001	3	6
BONE	MAX →	-0.622	-0.263	<.001	<.001	3	5
BONE	SLC30A8 →	+0.330	+0.217	.003	.004	3	5
BLOOD_Leukemia	DHX9 →	-0.311	-0.063	.001	.001	3	5
LUNG_SCLC	FPR2 →	-0.419	-0.181	.004	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLN1 by Regulation of protein maturation activity — LARGE_INTESTINE

Explore this box plot interactively →