Positive regulation of mRNA metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of mRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBL4A, HTATSF1, and RBM3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mRNA metabolic process activity versus UBL4A in COAD (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UBL4A →	-0.733	-0.393	.003	.004	3	1
COAD	HTATSF1 →	-0.641	-0.393	.002	.004	3	1
COAD	RBM3 →	-0.712	-0.393	<.001	.004	3	1
COAD	PBDC1 →	-0.785	-0.393	<.001	.004	3	1
COAD	PDZD11 →	-0.967	-0.393	.001	.004	3	1
COAD	EPHX2 →	+1.290	+0.394	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903313 vs UBL4A — COAD

Explore this scatter interactively →