Positive regulation of mRNA metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of mRNA metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB21, SLC22A18, and ALOX15B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB21 grouped by Positive regulation of mRNA metabolic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RAB21 →	+0.395	+0.267	<.001	.005	3	7
LUNG_NSCLC_LUAD	SLC22A18 →	+0.111	+0.080	.001	.008	3	6
BLOOD_Myeloma	ALOX15B →	+0.286	+0.238	<.001	.001	3	6
CNS	COL6A3 →	+0.312	+0.135	<.001	.001	3	6
CNS	USP51 →	+0.393	+0.123	<.001	.006	3	6
OVARY	USP53 →	+0.251	+0.158	.007	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB21 by Positive regulation of mRNA metabolic process activity — BLOOD_Myeloma

Explore this box plot interactively →