Negative regulation of mRNA metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of mRNA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP32_S682, EMD_S110, and SF3B3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of mRNA metabolic process activity versus ARHGAP32_S682 in LUAD (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ARHGAP32_S682 →	-0.331	-0.021	.009	.002	3	5
GBM	EMD_S110 →	+0.593	+0.039	.002	<.001	3	4
PDAC	SF3B3 →	+0.104	+0.016	.001	.006	3	4
LUAD	TRIM28 →	+0.184	+0.028	.008	.003	2	5
LUAD	CHD3 →	+0.242	+0.023	.001	.008	3	4
LUAD	CPSF3 →	+0.175	+0.037	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903312 vs ARHGAP32_S682 — LUAD

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