Positive regulation of regulated secretory pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of regulated secretory pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APOBR, PRAM1_S298, and MNDA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of regulated secretory pathway activity versus APOBR in CCRCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	APOBR →	+0.481	+0.047	<.001	<.001	3	6
PDAC	PRAM1_S298 →	+0.661	+0.040	<.001	<.001	3	6
CCRCC	MNDA →	+0.324	+0.028	.001	.001	3	5
LSCC	LMNB2 →	-0.209	-0.044	<.001	.001	3	5
LUAD	NFIX →	-0.444	-0.037	<.001	.001	3	5
LSCC	PLAU →	+0.537	+0.047	.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903307 vs APOBR — CCRCC

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