Positive regulation of regulated secretory pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of regulated secretory pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCF1, CHST14, and C11orf24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLCF1 grouped by Positive regulation of regulated secretory pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CLCF1 →	-2.106	-1.429	.001	.002	3	5
LUNG_NSCLC_LUAD	CHST14 →	-1.049	-0.934	.002	.001	3	5
SOFT_TISSUE	C11orf24 →	-0.927	-1.203	<.001	<.001	3	5
LUNG_SCLC	DDOST →	-1.135	-1.496	<.001	<.001	3	5
BONE	S100A6 →	-4.321	-1.295	.001	.001	3	4
BLOOD_Myeloma	TMBIM6 →	-0.668	-1.243	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLCF1 by Positive regulation of regulated secretory pathway activity — LIVER

Explore this box plot interactively →