Positive regulation of regulated secretory pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of regulated secretory pathway pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDRG1, PHGDH, and CD63, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of regulated secretory pathway activity versus NDRG1 in BONE (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NDRG1 →	+3.937	+0.368	.007	.008	3	7
BLOOD_Lymphoma	PHGDH →	-3.663	-0.181	.002	.006	3	6
BONE	CD63 →	+1.110	+0.292	<.001	.005	3	6
UPPER_AERODIGESTIVE_TRACT	TMPO →	-1.277	-0.144	.001	.006	3	5
UPPER_AERODIGESTIVE_TRACT	STRBP →	-1.187	-0.154	.001	.006	3	5
BONE	KLHL23 →	-1.528	-0.301	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903307 vs NDRG1 — BONE

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