Negative regulation of regulated secretory pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of regulated secretory pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRIX1, PPP1CC, and RARS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of regulated secretory pathway activity versus BRIX1 in CCRCC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BRIX1 →	-0.291	-0.522	.003	.009	3	4
CCRCC	PPP1CC →	-0.162	-0.385	.006	.002	3	4
CCRCC	RARS1 →	-0.338	-0.557	.001	.002	3	3
GBM	G3BP1 →	-0.237	-0.204	.007	.005	3	3
LUAD	CKS1B →	-0.569	-0.422	<.001	<.001	2	4
GBM	NPM1 →	-0.202	-0.145	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903306 vs BRIX1 — CCRCC

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