Negative regulation of regulated secretory pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of regulated secretory pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3C, CCRL2, and STK4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR3C grouped by Negative regulation of regulated secretory pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	POLR3C →	-0.821	-1.202	.001	.005	2	5
LARGE_INTESTINE	CCRL2 →	-1.462	-0.921	<.001	.001	3	4
SOFT_TISSUE	STK4 →	-1.016	-1.275	.004	.005	2	5
LUNG_SCLC	HS6ST2 →	+2.357	+0.984	.001	.001	3	4
SOFT_TISSUE	GSK3B →	-0.812	-1.068	.007	.007	3	4
SOFT_TISSUE	CYP20A1 →	-0.741	-1.797	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR3C by Negative regulation of regulated secretory pathway activity — SOFT_TISSUE

Explore this box plot interactively →