Negative regulation of regulated secretory pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of regulated secretory pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI2, PPP1R18, and AHNAK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of regulated secretory pathway activity versus GNAI2 in LIVER (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GNAI2 →	+1.482	+1.375	<.001	.001	3	7
STOMACH	PPP1R18 →	+3.085	+1.632	<.001	<.001	3	6
BLOOD_Lymphoma	AHNAK →	+3.238	+1.124	.001	<.001	3	6
LIVER	FLNA →	+2.503	+1.416	<.001	.001	2	7
LIVER	SHISA4 →	+3.530	+1.550	.001	<.001	3	6
LUNG_NSCLC_LUAD	CAVIN3 →	+2.124	+0.829	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903306 vs GNAI2 — LIVER

Explore this scatter interactively →