Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOL3, ERO1A, and ENO1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway activity versus NOL3 in CCRCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NOL3 →	+0.794	+0.344	.001	<.001	3	8
LUAD	ERO1A →	+0.674	+0.235	<.001	.003	3	6
BRCA	ENO1 →	+0.662	+0.185	<.001	<.001	3	6
BRCA	EGLN3 →	+0.768	+0.133	.003	.007	3	6
CCRCC	VEGFA →	+0.850	+0.240	.001	<.001	3	5
BRCA	S100A10 →	+1.041	+0.251	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903298 vs NOL3 — CCRCC

Explore this scatter interactively →