Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPTXR, PPP4R2, and CLEC16A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPTXR grouped by Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NPTXR →	-2.306	-1.070	<.001	.001	3	4
KIDNEY	PPP4R2 →	-0.642	-1.097	.001	<.001	3	4
KIDNEY	CLEC16A →	-0.811	-1.261	.002	.001	2	5
BONE	CDK12 →	-0.817	-1.294	.006	.002	3	3
PANCREAS	RNF185 →	-0.550	-0.960	<.001	.009	3	3
BREAST	CYRIB →	+0.864	+0.800	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPTXR by Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway activity — CNS

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