"Regulation of glutamate secretion, neurotransmission"

Across TCGA cell cohorts, RNA activity of the "Regulation of glutamate secretion, neurotransmission" pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AOC3, APEX2, and ZNF517, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AOC3 grouped by "Regulation of glutamate secretion, neurotransmission"-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AOC3 →	-1.265	-1.348	.003	<.001	3	5
BLOOD_Myeloma	APEX2 →	-1.037	-2.266	.006	<.001	3	4
PANCREAS	ZNF517 →	+0.829	+0.895	<.001	.005	3	4
BLOOD_Leukemia	MSX1 →	-2.081	-1.547	<.001	<.001	3	4
KIDNEY	FERMT2 →	-1.112	-0.857	<.001	.003	3	4
OESOPHAGUS	AOC2 →	-1.243	-1.247	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AOC3 by "Regulation of glutamate secretion, neurotransmission" activity — OESOPHAGUS

Explore this box plot interactively →