Protein localization to Golgi membrane

Across TCGA patient cohorts, RNA activity of the Protein localization to Golgi membrane pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB6B, UBAP2L, and TMCO1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to Golgi membrane activity versus RAB6B in LSCC (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RAB6B →	+1.214	+0.117	<.001	<.001	3	6
LSCC	UBAP2L →	+0.155	+0.082	.003	.001	3	5
CCRCC	TMCO1 →	+0.461	+0.049	<.001	.001	3	5
LSCC	MSN →	-0.284	-0.089	<.001	<.001	3	5
LSCC	AGFG2 →	-0.271	-0.095	.003	.001	3	5
COAD	TRIP10_S351 →	-0.269	-0.048	.007	.009	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903292 vs RAB6B — LSCC

Explore this scatter interactively →