Protein localization to Golgi membrane

Across TCGA cell cohorts, RNA activity of the Protein localization to Golgi membrane pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEDD, APOL3, and RAD54L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DEDD grouped by Protein localization to Golgi membrane-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DEDD →	-0.973	-1.205	.008	.005	2	5
OESOPHAGUS	APOL3 →	+2.449	+0.904	<.001	.009	3	4
OESOPHAGUS	RAD54L2 →	-0.742	-0.683	<.001	.007	3	4
KIDNEY	ST6GALNAC6 →	+0.853	+0.952	.007	.005	3	4
BLOOD_Myeloma	DUSP1 →	+1.694	+1.050	.006	.005	3	4
OVARY	PRKAR2A →	-0.735	-1.104	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DEDD by Protein localization to Golgi membrane activity — URINARY_TRACT

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