Regulation of potassium ion import

Across TCGA patient cohorts, RNA activity of the Regulation of potassium ion import pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCERG1P2, ST13P5, and PPP1R16B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of potassium ion import activity versus TCERG1P2 in LSCC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TCERG1P2 →	-0.479	-1.173	<.001	<.001	3	4
COAD	ST13P5 →	-0.393	-0.150	<.001	.003	3	3
LSCC	PPP1R16B →	-0.682	-0.820	.004	.003	3	3
UCEC	CD48 →	-0.624	-0.632	.005	.003	3	3
UCEC	AMDHD1 →	-0.485	-0.818	<.001	<.001	3	3
UCEC	TRAV2 →	-1.173	-0.792	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903286 vs TCERG1P2 — LSCC

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