Regulation of potassium ion import

Across TCGA cell cohorts, RNA activity of the Regulation of potassium ion import pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPT1, FAM160A1, and NOP10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of potassium ion import activity versus PNPT1 in LIVER (Pearson r = -0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PNPT1 →	-1.148	-0.398	.001	.002	3	6
LUNG_NSCLC_LUAD	FAM160A1 →	+1.072	+0.395	<.001	.004	3	6
OVARY	NOP10 →	-0.885	-0.439	.005	.007	3	6
URINARY_TRACT	ELFN2 →	+2.035	+0.190	.003	.007	3	6
LUNG_SCLC	SAMD9 →	+1.171	+0.197	<.001	.001	3	5
OESOPHAGUS	CRACD →	-0.987	-0.226	.006	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903286 vs PNPT1 — LIVER

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