Regulation of potassium ion import

Across TCGA cell cohorts, RNA activity of the Regulation of potassium ion import pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DLG1, SRM, and CDC37, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of potassium ion import activity versus DLG1 in OVARY (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DLG1 →	+0.896	+0.526	<.001	<.001	3	12
BONE	SRM →	-2.096	-0.784	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	CDC37 →	-1.144	-0.281	.007	.009	3	12
UPPER_AERODIGESTIVE_TRACT	EIF5B →	-1.678	-0.329	.002	<.001	3	12
SOFT_TISSUE	ATP1A1 →	+1.000	+0.276	<.001	<.001	3	12
CNS	EEF2 →	-0.878	-0.388	.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903286 vs DLG1 — OVARY

Explore this scatter interactively →