U2-type prespliceosome assembly

Across TCGA patient cohorts, RNA activity of the U2-type prespliceosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSH6, HDAC2, and RSF1_S397, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, U2-type prespliceosome assembly activity versus MSH6 in LSCC (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MSH6 →	+0.498	+0.054	<.001	<.001	3	8
HNSC	HDAC2 →	+0.259	+0.079	<.001	.001	3	7
LSCC	RSF1_S397 →	+0.728	+0.059	<.001	<.001	3	6
LSCC	SENP1 →	+0.186	+0.051	.005	.001	3	6
LSCC	SFPQ →	+0.209	+0.071	<.001	<.001	3	6
LSCC	SMARCA5 →	+0.330	+0.075	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903241 vs MSH6 — LSCC

Explore this scatter interactively →