U2-type prespliceosome assembly

Across TCGA patient cohorts, RNA activity of the U2-type prespliceosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT15, TAL1, and S1PR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, U2-type prespliceosome assembly activity versus GALNT15 in OV (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GALNT15 →	-1.126	-0.275	<.001	<.001	3	7
GBM	TAL1 →	-0.721	-0.320	.001	.001	3	7
OV	S1PR1 →	-0.727	-0.250	.001	.001	3	7
PDAC	LMOD1 →	-0.726	-0.313	<.001	<.001	3	7
LUAD	TEK →	-0.494	-0.185	.008	.002	3	7
PDAC	SYNC →	-0.692	-0.287	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903241 vs GALNT15 — OV

Explore this scatter interactively →