U2-type prespliceosome assembly

Across TCGA cell cohorts, RNA activity of the U2-type prespliceosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STARD13, PLPP1, and BMP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STARD13 grouped by U2-type prespliceosome assembly-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	STARD13 →	+1.488	+0.139	.006	.002	3	5
UPPER_AERODIGESTIVE_TRACT	PLPP1 →	+1.358	+0.195	.007	.006	3	4
PANCREAS	BMP2 →	+1.243	+0.211	.002	.004	3	4
BLOOD_Leukemia	PDHX →	-0.435	-0.115	.004	.005	3	4
CNS	SEC31A →	+0.612	+0.125	.002	.008	3	4
LUNG_NSCLC_LUAD	PDCD1LG2 →	+0.686	+0.106	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STARD13 by U2-type prespliceosome assembly activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →