U2-type prespliceosome assembly

Across TCGA cell cohorts, RNA activity of the U2-type prespliceosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX2, FAM117B, and RBMX, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, U2-type prespliceosome assembly activity versus CBX2 in BLOOD_Leukemia (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CBX2 →	+1.664	+0.147	<.001	<.001	3	9
LUNG_SCLC	FAM117B →	+0.863	+0.151	.001	<.001	3	8
LUNG_SCLC	RBMX →	+0.596	+0.198	<.001	<.001	3	6
SKIN	HNRNPDL →	+0.604	+0.164	<.001	<.001	3	6
LARGE_INTESTINE	POLG2 →	+0.681	+0.113	<.001	.003	3	6
BLOOD_Leukemia	CDCA7 →	+1.333	+0.108	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903241 vs CBX2 — BLOOD_Leukemia

Explore this scatter interactively →