Positive regulation of leukocyte tethering or rolling

Across TCGA patient cohorts, RNA activity of the Positive regulation of leukocyte tethering or rolling pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SEPTIN1, and STK10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte tethering or rolling activity versus RCSD1 in COAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RCSD1 →	+0.487	+0.054	<.001	<.001	3	9
OV	SEPTIN1 →	+0.811	+0.060	<.001	<.001	3	9
OV	STK10 →	+0.513	+0.072	<.001	<.001	3	9
GBM	WAS →	+0.511	+0.048	<.001	<.001	3	9
OV	CORO1A →	+0.863	+0.073	<.001	<.001	3	9
GBM	DOCK2 →	+0.452	+0.049	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903238 vs RCSD1 — COAD

Explore this scatter interactively →