Regulation of leukocyte tethering or rolling

Across TCGA patient cohorts, RNA activity of the Regulation of leukocyte tethering or rolling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP19, HBB, and PLK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte tethering or rolling activity versus MMP19 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MMP19 →	+0.960	+0.720	<.001	.004	3	5
CCRCC	HBB →	+1.034	+0.473	<.001	<.001	3	5
LSCC	PLK3 →	+0.588	+0.495	<.001	.006	3	5
PDAC	GATA6-AS1 →	+0.495	+0.523	.003	<.001	3	4
BRCA	MPP1 →	+0.415	+0.721	.001	.001	3	4
UCEC	KCNE1 →	+0.924	+0.640	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903236 vs MMP19 — BRCA

Explore this scatter interactively →