Regulation of leukocyte tethering or rolling

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte tethering or rolling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KANK2, BSCL2, and COMT, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KANK2 grouped by Regulation of leukocyte tethering or rolling-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KANK2 →	-1.277	-1.230	.001	<.001	3	7
BREAST	BSCL2 →	-1.002	-0.969	<.001	<.001	3	4
BLOOD_Leukemia	COMT →	-0.581	-0.962	.008	.002	3	4
STOMACH	GFOD1 →	-1.239	-1.148	.005	<.001	3	4
STOMACH	TMEM190 →	-0.342	-1.309	.002	<.001	3	4
STOMACH	ZSWIM8 →	-0.775	-1.551	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KANK2 by Regulation of leukocyte tethering or rolling activity — STOMACH

Explore this box plot interactively →