Melanosome assembly

Across TCGA patient cohorts, RNA activity of the Melanosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNIP1_S76, TOP1, and ANP32B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Melanosome assembly activity versus SNIP1_S76 in OV (Pearson r = -0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNIP1_S76 →	-1.006	-0.041	<.001	<.001	3	6
GBM	TOP1 →	-0.243	-0.043	<.001	<.001	3	6
GBM	ANP32B →	-0.334	-0.041	.007	.006	3	6
BRCA	ATAD2_S342 →	-0.720	-0.026	.002	.004	3	5
LSCC	C8orf33 →	-0.257	-0.037	<.001	<.001	3	5
LUAD	PDS5A_T1208 →	-0.419	-0.037	.005	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903232 vs SNIP1_S76 — OV

Explore this scatter interactively →