Melanosome assembly

Across TCGA patient cohorts, RNA activity of the Melanosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP1, MPP1, and NAGA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Melanosome assembly activity versus AKAP1 in LUAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKAP1 →	-0.371	-0.137	.004	.003	3	5
GBM	MPP1 →	+0.398	+0.130	.003	<.001	3	5
GBM	NAGA →	+0.446	+0.134	.001	.001	3	5
OV	IGKJ4 →	+1.559	+0.095	.004	.004	3	4
CCRCC	IL6R-AS1 →	+0.348	+0.094	.005	.009	3	4
BRCA	CCNB1IP1 →	-0.582	-0.089	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903232 vs AKAP1 — LUAD

Explore this scatter interactively →