Melanosome assembly

Across TCGA cell cohorts, RNA activity of the Melanosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFAP1L2, TMED5, and MSANTD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AFAP1L2 grouped by Melanosome assembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AFAP1L2 →	+1.958	+1.024	.004	.007	3	5
OVARY	TMED5 →	-0.579	-0.952	.008	.005	3	4
CNS	MSANTD2 →	-0.589	-0.818	.002	.004	3	4
OVARY	LDHA →	-1.432	-1.094	.004	.001	3	4
BLOOD_Lymphoma	FAM160A2 →	-0.919	-1.930	.002	<.001	3	4
BLOOD_Lymphoma	RAB10 →	-0.719	-1.676	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AFAP1L2 by Melanosome assembly activity — STOMACH

Explore this box plot interactively →