Melanosome assembly

Across TCGA cell cohorts, RNA activity of the Melanosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO5A, MICAL1, and RBM38, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Melanosome assembly activity versus MYO5A in SKIN (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MYO5A →	+1.150	+0.224	.002	.001	3	5
SKIN	MICAL1 →	+1.872	+0.280	<.001	.002	3	4
BREAST	RBM38 →	-0.874	-0.165	.002	<.001	3	4
OVARY	ABHD17A →	+0.764	+0.162	.003	.006	3	4
BLOOD_Leukemia	IFI44 →	-2.021	-0.176	.001	.004	3	4
OESOPHAGUS	MKRN3 →	-2.014	-0.163	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903232 vs MYO5A — SKIN

Explore this scatter interactively →