Regulation of endodermal cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of endodermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL6A3, LINC01929, and MMP14, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endodermal cell differentiation activity versus COL6A3 in GBM (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL6A3 →	+1.342	+0.136	.002	<.001	3	8
BRCA	LINC01929 →	+1.168	+0.150	<.001	<.001	3	7
BRCA	MMP14 →	+0.832	+0.128	<.001	<.001	3	7
LUAD	COL1A2 →	+1.456	+0.322	<.001	<.001	3	7
CCRCC	CERCAM →	+0.818	+0.249	<.001	.003	3	7
BRCA	LINC01614 →	+1.807	+0.201	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903224 vs COL6A3 — GBM

Explore this scatter interactively →