Regulation of endodermal cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of endodermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DKK1, MESP1, and GLIPR1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endodermal cell differentiation activity versus DKK1 in SOFT_TISSUE (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DKK1 →	+4.134	+0.246	<.001	<.001	3	12
BREAST	MESP1 →	-1.529	-0.217	<.001	<.001	3	11
BONE	GLIPR1 →	+4.752	+0.457	<.001	<.001	3	9
BONE	DCBLD1 →	+2.013	+0.335	<.001	<.001	3	9
SOFT_TISSUE	FILIP1L →	+2.439	+0.242	<.001	.001	3	9
SKIN	RRAGD →	-1.577	-0.235	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903224 vs DKK1 — SOFT_TISSUE

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