Regulation of endodermal cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of endodermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS27A, BRAF, and ARPP19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endodermal cell differentiation activity versus RPS27A in CNS (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RPS27A →	-0.761	-0.315	.002	.002	3	4
LUNG_NSCLC_LUAD	BRAF →	-0.905	-0.208	.003	<.001	3	3
LARGE_INTESTINE	ARPP19 →	-0.503	-0.151	<.001	.003	3	3
BREAST	CASP1 →	+2.257	+0.271	<.001	.002	3	3
OESOPHAGUS	SCUBE2 →	+1.545	+0.214	.005	.009	2	4
BREAST	GPNMB →	+4.556	+0.271	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903224 vs RPS27A — CNS

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