Negative regulation of calcium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SESTD1, CD302, and TTLL7, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion transmembrane transport activity versus SESTD1 in ESCA (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	SESTD1 →	+0.930	+0.049	<.001	<.001	3	25
UVM	CD302 →	+1.384	+0.036	<.001	<.001	3	24
SARC	TTLL7 →	+1.167	+0.031	<.001	<.001	3	23
SKCM	PRKACB →	+0.945	+0.021	<.001	<.001	3	23
UVM	RAB8B →	+0.967	+0.025	<.001	<.001	3	23
UCS	BCL2 →	+1.062	+0.042	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903170 vs SESTD1 — ESCA

Explore this scatter interactively →