Negative regulation of calcium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLIC2, NUP93, and PRKACB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion transmembrane transport activity versus CLIC2 in HNSC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLIC2 →	+0.441	+0.061	<.001	.007	3	7
LSCC	NUP93 →	-0.165	-0.053	<.001	<.001	3	7
GBM	PRKACB →	+0.301	+0.059	<.001	<.001	3	7
LSCC	ARRB1_S412 →	+0.325	+0.057	<.001	<.001	3	6
LSCC	RSL1D1 →	-0.381	-0.084	.002	<.001	3	6
BRCA	EIF3M →	-0.190	-0.034	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903170 vs CLIC2 — HNSC

Explore this scatter interactively →