Negative regulation of calcium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C16orf87, NFKBIE, and ESCO2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C16orf87 grouped by Negative regulation of calcium ion transmembrane transport-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C16orf87 →	+0.817	+0.787	.007	.007	3	3
LARGE_INTESTINE	NFKBIE →	+0.473	+0.621	.003	.007	3	3
BLOOD_Leukemia	ESCO2 →	+1.000	+0.289	.005	<.001	3	3
STOMACH	FGFBP1 →	-4.023	-0.358	.002	.003	3	3
BLOOD_Myeloma	ZNF552 →	+1.005	+1.192	<.001	.008	3	2
BLOOD_Myeloma	AGER →	+0.922	+0.512	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C16orf87 by Negative regulation of calcium ion transmembrane transport activity — BLOOD_Myeloma

Explore this box plot interactively →