Regulation of calcium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of calcium ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, LCP2, and ARHGAP45, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion transmembrane transport activity versus WAS in UCEC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WAS →	+0.536	+0.029	.002	.007	3	10
LSCC	LCP2 →	+0.554	+0.042	<.001	<.001	3	10
LSCC	ARHGAP45 →	+0.542	+0.043	<.001	<.001	3	10
LSCC	THEMIS2 →	+0.551	+0.044	<.001	<.001	3	9
LSCC	RCSD1 →	+0.573	+0.037	<.001	<.001	3	9
LSCC	RCSD1_S298 →	+0.810	+0.036	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903169 vs WAS — UCEC

Explore this scatter interactively →