Regulation of calcium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of calcium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCSAML, AHCY, and CD8B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion transmembrane transport activity versus GCSAML in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GCSAML →	+1.098	+0.541	.004	.005	3	3
COAD	AHCY →	-0.735	-1.774	.002	.009	3	2
COAD	CD8B →	+0.699	+1.812	.003	.009	3	2
BRCA	ADGRE1 →	+0.850	+0.528	<.001	.003	3	2
BRCA	AKAP5 →	+1.690	+0.455	.002	.007	3	2
BRCA	EVI2B →	+1.996	+0.558	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903169 vs GCSAML — BRCA

Explore this scatter interactively →