Regulation of calcium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PITPNM2, DOCK5, and CIB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion transmembrane transport activity versus PITPNM2 in LIVER (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PITPNM2 →	+1.705	+0.277	.001	.005	3	5
OVARY	DOCK5 →	+1.542	+0.200	<.001	.001	3	5
OVARY	CIB1 →	+1.006	+0.234	<.001	<.001	3	5
LIVER	ASAP2 →	+1.185	+0.231	.009	.009	3	5
SOFT_TISSUE	ZBTB46 →	-1.413	-0.215	.004	.007	3	5
BREAST	GREB1 →	-2.298	-0.238	.009	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903169 vs PITPNM2 — LIVER

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