Negative regulation of autophagy of mitochondrion

Across TCGA patient cohorts, RNA activity of the Negative regulation of autophagy of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALT2, DYNLRB2, and STK33, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of autophagy of mitochondrion activity versus B4GALT2 in PDAC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	B4GALT2 →	-0.252	-0.271	.006	.001	3	3
UCEC	DYNLRB2 →	+1.522	+0.384	<.001	.008	3	3
GBM	STK33 →	+0.418	+0.207	.005	.005	3	3
GBM	ESM1 →	-1.348	-0.233	<.001	.001	3	3
HNSC	GPRC5A →	+1.067	+0.532	.005	.008	2	3
PDAC	XPOT →	-0.312	-0.273	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903147 vs B4GALT2 — PDAC

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