Negative regulation of autophagy of mitochondrion

Across TCGA patient cohorts, RNA activity of the Negative regulation of autophagy of mitochondrion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIPA1_S817, TP53_S315, and SCNM1_S219, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of autophagy of mitochondrion activity versus SIPA1_S817 in UCEC (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SIPA1_S817 →	-0.684	-0.632	<.001	.001	3	3
LSCC	TP53_S315 →	+1.500	+0.384	<.001	.001	2	4
OV	SCNM1_S219 →	+1.448	+0.383	<.001	<.001	3	3
GBM	SYNE1_S6175 →	-0.773	-0.353	<.001	.002	3	3
OV	INPP5E_S99 →	+0.862	+0.242	<.001	.001	3	3
GBM	PFN1_S77 →	-1.072	-0.408	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903147 vs SIPA1_S817 — UCEC

Explore this scatter interactively →